My company has a semimonthly payroll.. Should it make any difference in the way I file taxes ? I recently used hnr block and it shows huge amount owed from my side. Please help

The payment schedule should make no difference in deducted taxes.

For example if you are paid $30,000 a year, it should not make any difference if the monies are paid to you weekly, bi-weekly, monthly.

$30,000 is $30,000.

How you are paid , weekly, bi weekly monthly, has no bearing at all. What makes a difference is if you had enough money being withheld from your check.

Also I will be blunt, HR Block is about the last place I would take my taxes to. I had to use them one year due to a family issue, and I had to set there and tell them everything they were forgetting, and had to pay way too much for it.
Then they forgot to file my state taxes and I never did get proper service or feedback or replys from them.

But your income, your deductions, and what you paid in, decides what your taxes should be.