I am a 57 year old woman in good physical and mental health. I am 5 ' 8 and I weigh 125 pounds. I eat well and am active. My physical in June was normal as was my blood work. I take no medication and I do not smoke.
For the last four months I have been struggling with a miserable irritation in my mouth. It came on quite suddenly while I was out of the country... some time between Turkey and Greece. The area facing my four front teeth, some of the gum above and below those teeth is affected and the similar area facing my lower teeth area is noticeably inflamed, painful and quite red (it is worse on the upper area than the bottom). He tissue appears to be wrinkled. It will occasionally split if I lift it up to look at it or laugh and smile too hard/wide. I seem to have adequate saliva... although that particular area will stick to my teeth. On occasion, I have awakened to find my upper lip noticeably swollen and distended but it went down fairly quickly... it continues to be only slightly swollen in the morning. (I wear a small night guard over my two front teeth but have worn it for years without incident).
I have twice visited my internist, once to my dentist as well as two visits to my dermatologist. I have been given a swish and swallow Nystatin, an oral Nystatin, two weeks of an antihistamine, a course of Valtrex, I have added Vitamin B and lately taken a course of Prednisone... and nothing has changed it. I am in the process of allergy testing.

Thanks for any thoughts or suggestions would be greatly appreciated.