Ever since I can remember I never had that many friends. It may have something to do with the fact I moved so much. But when I finally stopped moving in High school, I would get acquaintances, and when I thought I'd get a friend, they'd disappear in a week, and ignore me. I was very depressed all through high school, and very alone.

After high school I got a boyfriend who I followed to LA for (his) college, and for three years supported. Now we're engaged and he's got a great job, and is putting me through school. While at home I am very happy, at school I'm miserable. I do like what I'm studying, and most of the time I can absorb myself in it, but every time I talk to someone, teachers included, I feel as if I'm being regarded as insane.. One girl in most of my classes is the only exception, but all she does is talk about her best friends, which she has about 15 of (no joke). And I will listen for half a day, not saying a word and the second I say anything about me, she will interrupt and keep talking about herself.. If anything, she makes it worse..
I feel the only way I can overcome this is to stop caring. I have tried, but after 8 hours a day and a couple months, it becomes difficult.. Is there a better way to not care or just get over it? I don't want to feel so insignificant, lonely and insane.. (and I cannot talk to my fiancé when I'm at school, because he's at work)

Becoming a Narcissist won't cure anything. I'd talk to one of your better friends and ask them honestly what others may see in you that's off-putting. Obviously your friends will see and focus on your good aspects, but they can and will see some of your negative aspects. And don't get me wrong. We ALL have our negative aspects. Nobody is perfect. I joke the last perfect person got cruscified over 2,000 years ago. It help you keep it in perspective.

Perhaps its just a habit you have that you can work on once you identify it, but also consider, everyone is different. You can't make everyone like you. And you can't like everyone else either.

Based on the girl you mention above... she seems quite conceited by how you describe her. That is not what you wish to emulate either.

Consider this... College is for education... not socializing, for what you are paying that should help you keep your focus. You want and need the best grades you can get, it matters on how good a job you might land at graduation. If you focus on that... there really isn't that much spare time to worry about socializing. I've been to college, I took a full course load and really had little time to be screwing around as I did not live on campus and had to commute.

If you have time to find a part time job in the evenings... Get one where you are forced to deal with customers all the time. You will be amazed how that alone can desensitize you to many social fears you might have.