Any idea on the long term efficiency of clomipramine

"Efficiency" in what regard?

In the meantime the following link for MedlinePlus will provide you with medically reviewed information on Clomipramine. It is a Q&A format and easy to navigate. I commend for trying to learn as much as possible about your medication. Another excellent source for information is your pharmacist.

Clomipramine: MedlinePlus Drug Information (http://www.nlm.nih.gov/medlineplus/druginfo/meds/a697002.html)

Ran a quick check on this and the MedlinePlus states as follows: "....Cigarette smoking may decrease the effectiveness of this medication." See http://www.nlm.nih.gov/medlineplus/druginfo/meds/a697002.html#precautions

That could be the problem. You may want to check with the pharmacy where you filled the prescription (can probably just call) or with the prescribing physician, which ever is available.

This class of drug has an extensive list of contraindications (things not to do and side effects). So I wouldn't delay. Hope this helps.

Thanks much for your great input, yeah I saw it on the website. But my gp insists there shouldn't be a problem. I'll see what happens if I reduce the amount of smokes.

Glad to help. Please keep me posted. I'm very interested in drug pharmacokinetics (how they act in your system) and prescription follow-up practices.