I know it's necessary to hit studs when installing a staircase banister. The wall I'm working with is only 6 feet long and of course the studs aren't exactly where I want them. Based on my measurements and the picture below, I think I only have two choices.

Choice 1: Mount a bracket on each stud that the banister passes (studs 2-5). This would put 4 brackets on the banister, all hitting studs. The bottom edge of the banister is 18" from the bracket on stud 2. With there being 4 brackets, I know the banister will be plenty strong, but for looks I think I would want to add another bracket 6" from the bottom.

Choice 2: Use brackets that hit studs 2 and 5. Then install brackets A, C, and D into the drywall to make things look even. This way would only have brackets hitting 2 studs.

I like the look of choice 2 better because the way the brackets are spread out makes the whole thing look more even. With choice 1, the brackets will be equal distances apart with the exception of the bottom two.

My gut tells me to go with choice 1 because the banister will be more secure. What do you guys think?

Do B, C and E. "C" is for appearance only. Use plastic anchors when mounting "C".

A,B,C,D,E would be overkill and would be unsightly.

A,C,E would not be strong enough

After you are through, you will never notice the differences in distance between the ends of the handrail and brackets.

I think it depends on where this thing is, but as you said it must be noticeable. I have a ~9' bannister with three brackets and the middle bracket is way off. It's plenty strong supported in two places.

Although a lot more work and if the wall is drywall, you could always cut the drywall out and add a cross stud and re-paint. Just center the bracket "C".

How about just using the studs "B and E and make the end distances the same? Then make the middle one fake. Molly bolts might be better in this instance. Shorten the bannister, so it looks right.

I don't see any reason to use 4 brackets. 3 is probably more pleasing to the eye.