I have a problem with my great peranese puppys sheading she sheads all the time and I am sick of it is there any shampoh or any thing or do I have to live with it :confused:

There is an amazing brush called the Furminator. It removes all the dead undercoat and loose top hair. After brushing, you will have enough fur to be able to create another dog -- or a blanket. (One person I know turns the hair into yarn to make mittens.) The Furminator is not cheap but it's worth its weight in gold. Check for sales at pet supply stores and on e-Bay.

FURminator (http://www.furminator.com/)

Sadly you have picked a breed that sheds. There are products you can buy (like the one Wondergirl mentioned) that will decrease the shedding, but there is no way to completely end shedding in a dog that sheds.