When I run Visual Basic 6.0, I got a error - 'Run time error 3170 - Could'nt find installable ISAM'.

I'm using Access 2000 as the database.

Here's a tutorial about using Excel in VB. The principles are the same for Access.

Tutorial/FAQ: How to Automate Excel from VB6 (or VB5/VBA) - VBForums (http://www.vbforums.com/showthread.php?t=391665)

Also, an old Microsoft KB document says that the ISAM driver requires manual registration but I'm not sure this applies to your situation:

ACC97: Microsoft Exchange ISAM Driver Requires Manual Registration (http://support.microsoft.com/kb/161173)