What you are dealing with is a 'workplace bully'. It is a relatively new phenomenon that over the past few years has resulted in awareness training. That has come about because the stress caused by workplace bullies costs money in sick days and benefits. I have also heard that companies not addressing issues caused by these bullies, are subject to legal troubles too.
I recently worked with a co-worker like you described, only female. She used information on me (personal), to spread rumours, and cause me a lot of grief. I reported her, and the company had followed the policy to deal with this type of abusive behaviour.
She was given a warning, told to stop, and failure to do so would result in instant dismissal.
Ignoring people like this isn't the answer. They are manipulative, self-centered, and driven to use anybody in their way to get ahead.
I think that if you confront him, or speak to the supervisor, you may or may not curb his behaviour. But, if he's on a path to make your life (and probably others) miserable, it might be a good idea to recognize the type of bully he is, and research how to deal with him.
http://www.safety-council.org/info/OSH/bully.html