I did a bit of research on the subject because I used to take it daily for migraines....
So, this is the first thing to read:
DRUG INTERACTIONS: Ibuprofen is associated with several suspected or probable interactions that can affect the action of other drugs. Ibuprofen may increase the blood levels of
lithium (Eskalith) by reducing the excretion of lithium by the kidneys. Increased levels of lithium may lead to lithium toxicity. Ibuprofen may reduce the blood pressure-lowering effects of drugs that are given to reduce blood pressure. This may occur because prostaglandins play a role in the regulation of blood pressure. When ibuprofen is used in combination with aminoglycosides [for example,
gentamicin (Garamycin)] the blood levels of the aminoglycoside may increase, presumably because the elimination of aminoglycosides from the body is reduced. This may lead to aminoglycoside-related side effects. Individuals taking oral blood thinners or anticoagulants [for example,
warfarin (Coumadin)] should avoid ibuprofen because ibuprofen also thins the blood, and excessive blood thinning may lead to bleeding.
SIDE EFFECTS: The most common side effects from ibuprofen are
rash,
ringing in the ears,
headaches, dizziness, drowsiness,
abdominal pain,
nausea,
diarrhea,
constipation and
heartburn. NSAIDs reduce the ability of blood to clot and therefore increase bleeding after an injury. Ibuprofen may cause ulceration of the stomach or intestine, and the ulcers may bleed. Sometimes, ulceration can occur without abdominal pain, and black, tarry stools, weakness, and dizziness upon standing (orthostatic hypotension) due to bleeding may be the only signs of an ulcer. NSAIDs reduce the flow of blood to the kidneys and impair function of the kidneys. The impairment is most likely to occur in patients who already have impaired function of the kidney or
congestive heart failure, and use of NSAIDs in these patients should be cautious. People who are allergic to other NSAIDs, including
aspirin, should not use ibuprofen. Individuals with
asthma are more likely to experience allergic reactions to ibuprofen and other NSAIDs. Fluid retention (
edema), blood clots,
heart attacks,
hypertension and
heart failure have also been associated with the use of NSAIDs.
Hope this helps!
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