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"Best" is all about exposure: Dollars per number of people who see or hear the ad.
It will be best to identify what you can afford to spend on advertising, then seek out the venue where that amount will get you the most number of people who see or hear it.
Our company has done direct mail and TV advertising for over 7 years now. The TV adds have really worked well for us. ( but direct mail did great too for many years, but for number of calls for dollar spent, the TV has really done well
Most forget I am in the Medical Supply Business, I am over all the companies sales here in TN. I am even going for my Practitioners certification next Thursday
But we used to do direct mail only and started to do TV ad about a year or so ago, now we only do TV adds.