Can anyone distinguish between denaturation and precipitation of protein.

Check it out: Denaturation Protein

Precipitation involves something coming out of solution... not soluble... with proteins this is done often by adding a salt that will "tie up" the water that is forming a hydration layer around the protein. Just think the salt competes with the protein for interaction with the water. In time, with enough salt, hydrophobic regions of the protein become exposed and the proteins can aggregate and eventually fall out of solution. Precipitation is tied to solubility. Solubility is tied to an ability to have water surround the protein and interact well.

Denaturation involved changing the shape that the structure would naturally take... salts can be used to do this also, but there are other means, such as heat, that can be used. Things like changing the pH can change conformation, the shape, of the protein. So here we are talking not about trying to break the bonds between water and the protein, but were are talking about the interactions between different regions of the proteins as well. This isn't about making it come out of solution in aggregates. Its about changing how the protein comforms. Make your hand into a fist versus stretched out to catch a ball. Same primary structure, differect overall shape.

Thank u for tat kp2171 tat was a great help

From flick