| If your plane is running late, let the steward/ess know you have a connecting flight. Depending on how late you are running they might hold the plane for you (MIGHT!). If your flight is delayed at landing and it is the fault of the airline, typically they will book you on a later flight (if there is one) or put you up in a hotel for the night. This will only be at their expense if you miss your flight because THEY are running late - if you miss it because YOU don't get to the gate in time, it's not their problem. You can still contact any of the agents for the airline for rebooking and suggestions for hotels, etc. There might be fees for changing your flight, keep this in mind.
I haven't been to Frankfurt in years, and when I went I was staying and it was pre-9/11, so I don't know what the security guidelines are. You will probably have to go through customs when you land in Germany, but they might (MIGHT!) have a "continuing" area where you go right to the gates. If you have to go through customs you might also have to re-enter the gates terminal and go back through security - it all depends on the airport layout and their policies. I'm sorry, I just don't know for sure. If you used a travel agent when you booked this flight, contact him/her and ask. Either way, you might want to try and re-book your flight to allow more layover time. You are cutting it really close with only having 45 mins. Even if you land on time and don't have go through customs, you still have to de-plane and get to the next terminal. De-planing alone can take 30mins depending on where on the plane you are sitting. | 
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